The 49ers lost the most games to injury last season, and so far 2025 hasn't been much better. With the receiver room especially banged up, rookie Jordan Watkins was stepping up, catching a 50-yard pass in the preseason opener. Then he suffered a high ankle sprain. San Fran is the NFL's most top-heavy team: a slew of superstars backed up by limited depth. In their 30-9 loss to Denver, the 49ers saw each of their QBs throw an INT. Mac Jones played well, but Carter Bradley and Tanner Mordecai combined to go 9 of 20 for 53 yards. Geno Smith should play more Saturday than he did in Vegas' preseason opener, and he'll be followed by Aidan O'Connell and exciting rookie Cam Miller.