Xavier vs. UConn odds, prediction: 2026 Big East Conference men's college basketball picks from proven model

The third-ranked UConn Huskies look for the season sweep against the Xavier Musketeers in a key Big East Conference matchup on Tuesday. Xavier is coming off a 68-66 win over DePaul on Saturday, while Connecticut cruised to an 85-58 win at Creighton that same day. The Musketeers (12-10, 4-7 Big East), who are tied for sixth in the league, are 1-5 on the road this season. The Huskies (21-1, 11-0 Big East), who have won 17 in a row, are 11-1 on their home court.

Tip-off from PeoplesBank Arena in Hartford, Conn., is set for 7 p.m. ET. UConn leads the all-time series 8-5, including a 90-67 win at Xavier on Dec. 31. UConn is a 17.5-point favorite in the latest Xavier vs. UConn odds from DraftKings Sportsbook, while the over/under for total points scored is 147.5. 

Before making any Xavier vs. UConn picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 14 on a sizzling 10-1 run on its top-rated over/under college basketball picks dating back to last season, and is on an 8-1 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

The model has simulated Xavier vs. UConn 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits over 50% of the time!

So who wins Xavier vs. UConn, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!