Xavier vs. St. John's odds, line, spread: Proven model reveals college basketball picks, predictions for Feb 16, 2022

Xavier hosts the first of two Big East matchups with St. John's on Wednesday evening at 6:30 p.m. at the Cintas Center. The two played on the same date one year ago, and St. John's beat Xavier for the first time in 12 meetings with their conference opponent. The Musketeers are 12-3 at home this season, while St. John's is just 3-5 on the road. St. John's guard Julian Champagnie is the top scorer from either program, and has averaged 18.3 points and 6.8 rebounds per game this season.

The Musketeers are favored by 7.5 points in the latest Xavier vs. St. John's odds from Caesars Sportsbook, and the over-under is set at 149.5. Before you make any St. John's vs. Xavier picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Xavier vs. St. John's 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins Xavier vs. St. John's? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!