White Sox vs. Guardians odds, lines: Advanced computer model reveals picks for Wednesday's matchup

After two days of postponements, Chicago and Cleveland will finally begin their series on Wednesday afternoon in the first game of a doubleheader. The White Sox and Guardians were supposed to play on Monday and Tuesday, but weather nixed both of those games. Chicago comes into this series off a loss to Tampa Bay on Sunday, while Cleveland is on a three-game losing streak. First pitch at Progressive Field is set for 2:10 p.m. ET.

Cleveland is listed as a -140 favorite (risk $140 to win $100) on the money line in the latest Guardians vs. White Sox odds from Caesars Sportsbook, while the over-under for total runs scored is eight (see the latest lines for every game on our MLB odds page).

Before making any White Sox vs. Guardians picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 14-4 roll on top-rated MLB money-line picks through two weeks, returning over $800 for $100 players. Anyone following it has seen HUGE returns!

The model knows that the White Sox have won six of their eight games since losing at Detroit to open the season. They are facing a Cleveland offense that has cooled off of late, scoring just four total runs during its three-game sweep at the hands of San Francisco over the weekend. Chicago starter Dallas Keuchel has had success against Cleveland during his career, going 4-2 with a 3.53 ERA in 11 starts. White Sox first baseman Jose Abreu ranks third in franchise history in home runs (229) and fifth in extra-base hits (510). 

The model also knows Cleveland's offense erupted for 44 runs during its four-game winning streak last week and should not be judged based on a series against San Francisco, which has one of the best pitching staffs in the MLB. The Guardians struggled with runners in scoring position on Sunday, going 1 of 8 and stranding six runners. Right-handed pitcher Shane Bieber has dominated Chicago during his career, posting a 5-2 record with a 2.55 ERA in 12 career starts. He has allowed just a pair of hits in each of his two outings this season. 

Now, it has set its sights on Guardians vs. White Sox. We can tell you the model is projecting 8.4 total runs, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Guardians vs. White Sox? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the White Sox vs. Guardians money line you should be all over on Wednesday, all from the model on a roll on MLB picks!