UConn vs. St. John's odds, prediction: 2026 Big East Conference men's college basketball picks from proven model

The top two teams in the Big East clash when the third-ranked UConn Huskies battle the No. 22-ranked St. John's Red Storm in a key matchup on Friday night. Connecticut is coming off a 92-60 win over Xavier on Tuesday, while St. John's defeated DePaul 68-56 that same night. The Huskies (22-1, 12-0 Big East), who have won 18 games in a row, are 7-0 as the road team this season. The Red Storm (17-5, 10-1 Big East), who have won eight in a row, are 10-2 as the home team in 2025-26.

Tip-off from Madison Square Garden in New York is set for 8 p.m. ET. St. John's leads the all-time series 39-34, including wins in each of the last two meetings. UConn is a 1.5-point favorite in the latest UConn vs. St. John's odds from DraftKings Sportsbook, while the over/under for total points scored is 145.5. 

Before making any UConn vs. St. John's picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 14 on a sizzling 10-1 run on its top-rated over/under college basketball picks dating back to last season, and is on an 8-1 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

The model has simulated UConn vs. St. John's 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins UConn vs. St. John's, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!