Spain vs. Portugal odds, predictions: 2026 World Cup Round of 16 picks from proven soccer expert

The Iberian Derby will be renewed on Monday in a Round of 16 match at the World Cup 2026 as Spain take on Portugal. These neighboring nations have faced off over 40 times previously, but this will be just their third FIFA World Cup meeting. Lamine Yamal and Spain won their first knockout stage match, 3-0, over Austria, while the Portuguese, behind Cristiano Ronaldo, defeated Croatia, 2-1, in the Round of 32. Spain prevailed and there was a draw across their prior two World Cup matchups. Trade Spain vs. Portugal at Kalshi, where new users get a $15 bonus after $15 in trades with the Kalshi promo code SPORTSLINE15:

Kickoff is at 3 p.m. ET from Dallas Stadium. The latest Portugal vs. Spain odds from FanDuel Sportsbook list Spain at -115 (risk $115 to win $100) on the 90-minute money line, with Portugal at +310 and a draw at +260. The over/under for total goals is 2.5. Spain are -225 to advance, with Portugal at +180.

Before locking in any Spain vs. Portugal picks or World Cup 2026 predictions, you need to see what proven soccer expert Jon "Buckets" Eimer has to say.

Eimer is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, he has covered the English Premier League, Champions League, Serie A, the FA Cup, and more. He's been red-hot on his soccer betting picks in 2026, posting a 31-13-2 record and returning over $1,200 of profit on his Champions League picks. He's also off to a fast start in the World Cup, and is on an 25-16-2 run on WC picks (+262). Anyone wanting to follow his World Cup betting advice at sportsbooks and on betting apps could see BIG returns!

Now Eimer has turned his attention to Spain vs. Portugal in the 2026 World Cup, and revealed his best bets. 

One of Eimer's Portugal vs. Spain predictions: He is leaning Over on total goals (2.5).

Eimer has also found a critical x-factor and locked in three best bets, including a plus-money prop on a player who looks "unstoppable!"

What are the best bets for Spain vs. Portugal? ... Join SportsLine now to see Jon Eimer's best bets for Portugal vs. Spain, all from the soccer expert who is on an 25-16-2 run on World Cup picks!

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