Barcelona look to maintain their lead atop the Spanish La Liga table when they visit Real Betis for a Wednesday matchup at Benito Villamarin Stadium. Barca (15-2-1) have a five-point lead over rival Real Madrid, who face Valencia on Thursday. Betis (9-4-5) are sixth in La Liga's table but just three points behind fourth-place Atletico Madrid. The teams met in the Spanish Supercopa semifinals on Jan. 12, with Barcelona prevailing on penalties after a 2-2 draw.

Kickoff is set for 3 p.m. ET in Seville, Spain. Barcelona are -135 favorites (risk $135 to win $100) in the latest Real Betis vs. Barcelona odds from Caesars Sportsbook, while Betis are +380 underdogs. A draw is +265, and the over/under for total goals is 2.5. (For more soccer coverage, click here.)

Before you make any Barcelona vs. Real Betis picks or Spanish La Liga predictions, you must see what renowned soccer bettor Jon Eimer has to say.

Eimer, widely known as "Buckets," is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, Eimer has covered the English Premier League, Serie A, the FA Cup and much more. 

He is 22-7 (+17.03) on all soccer article predictions for SportsLine in 2023, bringing a profit of more than $1,700 for $100 bettors. He also is a stunning 64-28-1 (69%) on his Premier League picks for SportsLine since the start of 2022, for a profit of more than $3,000. Anyone who follows him is WAY UP!

Eimer knows that Barcelona have won seven of the past eight meetings in all competitions and scored at least twice in each victory. They had at least three goals in five of them. La Blaugrana enter this match on a 13-game unbeaten run (11-2-0) in all competitions and have the league's top scorer. Robert Lewandowski has 13 goals in league play and 22 in 22 matches overall. The Barca back line has allowed an astonishing six goals in 18 league matches. 

But Eimer also has taken into account that Betis are 6-4-2 in their past 12 overall matches. They also have been excellent defensively, conceding 14 goals in their 18 games. They are 5-2-1 on their home turf in Seville and have a 12-5 goal advantage at Benito Villamarin. Barcelona's only loss came on the road, and five of their six goals conceded came away from home. Borja Igelesias is the top scorer with nine goals, tied for third in La Liga.

Now, Eimer has taken an in-depth look at the Real Betis vs. Barcelona matchup and locked in his picks. He is taking Over on the total and has two other best bets and his full breakdown of the match. You ABSOLUTELY need to see his picks and analysis before making any selections of your own. 

What is the best bet you can make for the Barcelona vs. Real Betis La Liga match on Wednesday? And where does all the betting value lie? ... Join SportsLine now to see Jon Eimer's picks for Real Betis vs. Barcelona, all from the expert who is up more than $1,700 on his soccer picks for SportsLine in 2023!