South Carolina vs. Clemson odds, line, spread: Proven model reveals college football picks, predictions for Week 13, 2021

The South Carolina Gamecocks will take on the Clemson Tigers at 7:30 p.m. ET on Saturday at Williams-Brice Stadium. The Gamecocks are 6-5 overall and 5-1 at home, while Clemson is 8-3 overall and 2-2 on the road. Clemson is ranked second in the Atlantic Division; USC is ranked fifth in the East Division. 

The Tigers are favored by 11.5 points in the latest South Carolina vs. Clemson odds from Caesars Sportsbook, and the over-under is set at 43. Before you make any Clemson vs. South Carolina picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has simulated South Carolina vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins South Carolina vs. Clemson? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!