Seahawks vs. Cardinals betting preview: Odds, picks, props, trends, injuries, weather and more for Week 4 Thursday Night Football

Home teams are 3-0 on Thursday Night Football so far this season, but 1-2 ATS entering Week 4's NFC West matchup as Seattle (2-1) visits Arizona (2-1). That might be the best division in football with all four teams above .500 -- no other division can say that. Both of these clubs are 0-1 in divisional play, with each losing to unbeaten San Francisco. A second early loss would likely be costly. The Seahawks are -1.5 with a total of 43.5 for the typical 8:15 ET kick on Prime Video.

Both defenses have excelled in the early going under defensive-minded head coaches Mike Macdonald (Seahawks) and Jonathan Gannon (Cardinals). Seattle is allowing just 15.7 points per game and hasn't conceded more than 17 yet, second only to Green Bay in the NFL. Arizona is giving up 17.0 PPG, tied for fifth in the league and the fewest PPG allowed by the franchise through three games since 2015.

This is the first of four prime-time appearances for the Seahawks and first of two for the Cardinals -- although later ones could be flexed out or in. Seattle has won a franchise record seven consecutive road games and is 8-1 on the road under Macdonald. The team is 10-1-1 at State Farm Stadium in Glendale since 2013.

There have been 15 games decided by a game-winning score in the final three minutes of regulation or in overtime, the most such games through Week 3 in NFL history.  

We'll take you through every aspect of the Seahawks vs. Cardinals game that you need to know before you lock in your bets, including SportsLine expert picks, props, trends, DFS, injury information and everything else that will help you know which plays are worth making for the primetime matchup.

Who wins Seahawks vs. Cardinals in the Week 4 Thursday night game, and what critical X-factor makes one side of the spread hit HARD? Join SportsLine right now to see everything you need to know to dominate your Thursday Night Football bets, plus get expert picks, model sims, prop bets, DFS lineups, and more!