Saints vs. Panthers odds, line, spread: Proven model reveals NFL picks, predictions for Week 17, 2022

An NFC South battle is on tap between the New Orleans Saints and the Carolina Panthers at 4:25 p.m. ET on Sunday at Caesars Superdome. New Orleans is 7-8 overall and 2-5 at home, while Carolina is 5-10 overall and 3-4 on the road. The Saints are ranked third in the NFC South; the Panthers are ranked fourth. 

New Orleans is favored by 7 points in the latest Saints vs. Panthers odds from Caesars Sportsbook, while the over-under is set at 38.5. Before you make any Panthers vs. Saints picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up over $7,100 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 17 of the 2021 season on an incredible 134-96 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has simulated Saints vs. Panthers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Saints vs. Panthers? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.