The Cincinnati Reds battle the Pittsburgh Pirates in the second of a four-game series between National League Central rivals on Friday. Pittsburgh is coming off a 7-0 win in Thursday's series opener. The Reds (60-56), who have dropped two in a row, are 27-30 on the road this season. The Pirates (50-66), who have won six of their past 10 games, are 33-27 on their home field in 2025.

First pitch from PNC Park in Pittsburgh is set for 6:40 p.m. ET. The Reds have won four of the past seven meetings with the Pirates. Cincinnati is a -124 favorite on the money line (risk $124 to win $100) in the latest Reds vs. Pirates odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 7.5 in the latest MLB odds. 

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The model has simulated Reds vs. Pirates 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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