Pittsburgh vs. Clemson odds, line, spread: Proven model reveals college football picks, predictions for Week 8, 2021

This season's Clemson team is a departure from the Tigers teams of recent years, but it will try and take a win from its Week 8 matchup with No. 23 Pitt on Saturday. Last year, Clemson averaged 43.5 points per game, but this season the offense is scoring 20.5, which is the 17th-lowest mark among all FBS teams. Meanwhile, Pitt is 5-1 and sits in first place in the ACC Coastal Division.

Kick-off for the game is 3:30 p.m. ET at Heinz Field. Senior QB Kenny Pickett has been one of the nation's top passers, which is why the Panthers are favored by 3.5 points in the latest Pittsburgh vs. Clemson odds from Caesars Sportsbook, and the over-under is set at 47. 

Before making any Clemson vs. Pittsburgh picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Pittsburgh vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. 

So who wins Pittsburgh vs. Clemson? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!