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Phillies vs. Guardians line, odds, start time, spread pick, best bets for May 11 Sunday Night Baseball matchup from proven model

SportsLine's projection model, which is on a profitable 10-5 run, has locked in its MLB picks for Phillies vs. Guardians on Sunday Night Baseball

ByUpdated: May 11, 2025 9:27PM UTC . 2 min read

The Philadelphia Phillies take on the Cleveland Guardians in the third and decisive game of their interleague series on Sunday Night Baseball. The Phillies (23-16), second in the National League East, have won four of five. The Guardians (23-16), second in the American League Central, have won five of seven.

First pitch from Progressive Field in Cleveland is set for 7:10 p.m. ET. The Guardians have won six of the last nine meetings with the Phillies. Philadelphia is a -175 favorite on the money line (risk $175 to win $100) in the latest Phillies vs. Guardians odds, while the total number of runs Vegas thinks will be scored, or the over-under, is 7. 

Before making any Phillies vs. Guardians picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 7 of the 2025 MLB season on a 10-5 run (67%) on top-rated MLB money-line picks. Anybody following could have seen strong returns!

The model has simulated Phillies vs. Guardians 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

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Daniel Kohn

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