Penn State vs. No. 1 Ohio State odds, line: 2025 college football picks for Week 10 predictions from proven model

The top-ranked Ohio State Buckeyes will look to keep the Penn State Nittany Lions winless in Big Ten Conference play when they meet in a key matchup on Saturday. Both teams are coming off a bye after Penn State dropped a 25-24 decision at Iowa, while Ohio State downed Wisconsin 34-0 on Oct. 18. The Nittany Lions (3-4, 0-4 Big Ten), who have lost four in a row, are 0-2 on the road this year. The Buckeyes (7-0, 4-0 Big Ten), who have won 11 games in a row dating back to last season, are 4-0 on their home field.

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Kickoff from Ohio Stadium in Columbus, Ohio, is at noon ET. Ohio State leads the all-time series 25-14, including a 13-2 edge in games played at Ohio Stadium. The Buckeyes are 18.5-point favorites in the latest Penn State vs. Ohio State odds, while the over/under for total points scored is 44.5 via SportsLine consensus. 

Before making any Penn State vs. Ohio State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and it enters Week 10 on a profitable 47-33 combined run on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated Penn State vs. Ohio State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in almost 70% of simulations.

So who wins Penn State vs. Ohio State, and which side of the spread hits almost 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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