Penn State vs. Michigan odds, prediction: 2026 Big Ten Conference men's college basketball picks from proven model

The second-ranked Michigan Wolverines take on the Penn State Nittany Lions in Big Ten Conference action on Thursday night. Penn State is coming off a 77-75 win over Minnesota on Sunday, while Michigan defeated Michigan State 83-71 on Friday. The Nittany Lions (10-12, 1-10 Big Ten), who are 0-4 against ranked opponents this season, are 1-5 on the road. The Wolverines (20-1, 10-1 Big Ten), who are 15-1 against unranked foes, are 10-1 on their home court.

Tip-off from Crisler Center in Ann Arbor, Mich., is set for 7 p.m. ET. Michigan leads the all-time series 41-17, including a 74-72 win at Penn State on Jan. 6. Michigan is a 24.5-point favorite in the latest Penn State vs. Michigan odds from DraftKings Sportsbook, while the over/under for total points scored is 163.5. 

Before making any Penn State vs. Michigan picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 14 on a sizzling 10-1 run on its top-rated over/under college basketball picks dating back to last season, and is on an 8-1 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

The model has simulated Penn State vs. Michigan 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits over 70% of the time!

So who wins Penn State vs. Michigan, and which side of the spread hits over 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!