Panthers vs. Packers prediction, odds, line, spread, time: 2023 NFL picks, Week 16 best bets from proven simulation model

The Carolina Panthers and the Green Bay Packers are set to square off in an NFC battle on Sunday at Bank of America Stadium in Charlotte. Carolina is 2-12 overall and 2-4 at home, while Green Bay is 6-8 overall and 2-5 on the road. The Panthers are coming off a 9-7 win over the Atlanta Falcons, while the Packers lost to the Tampa Bay Buccaneers 34-20 in Week 15. The loss was Green Bay's second straight and dropped them to 11th place in the NFC playoff race.

Kickoff is at 1 p.m. ET. The Packers are favored by 4 points in the latest Panthers vs. Packers odds, and the over/under is 38.5 points. Before making any Panthers vs. Packers picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2023 NFL season on an incredible 178-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 32-21 roll on top-rated NFL picks since Week 7 of last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model has simulated Panthers vs. Packers 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that has all the value. 

So who wins Panthers vs. Packers, and which side of the spread has all the value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks!