No. 9 Duke vs. Louisville odds, line: Proven college basketball model reveals spread pick for Saturday's ACC showdown

The No. 9 Duke Blue Devils will try to keep pace with Miami in the ACC standings when they take on the Louisville Cardinals in a key conference game on Saturday at the KFC Yum! Center in Louisville, Ky. The Blue Devils (16-3, 6-2 ACC) enter the game tied with Notre Dame for second in the conference. Meanwhile the Cardinals (11-9, 5-5) sit in eighth place. 

Tipoff is set for noon ET. The Blue Devils are favored by 6.5 points in the latest Duke vs. Louisville odds from Caesars Sportsbook, while the Over/Under for total points scored is 142. (See up-to-date odds for every game this week on our college basketball odds page.)

Before making any Louisville vs. Duke picks, be sure to check out what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every Div. I college basketball game 10,000 times. It enters Week 12 of the season with a 49-36 record on all top-rated college basketball picks, returning almost $700. Over the past five-plus years, the proprietary computer model has generated an impressive profit of $2,800 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows that the Duke's Paolo Banchero is the potential No. 1 overall pick in this year's NBA Draft. A 6-foot-10 freshman from Seattle, Banchero ranks fifth in the ACC in scoring (17.9 points per game), sixth in rebounding (7.9 rebounds per game) and eighth in field goal percentage (51.0) and leads all true freshmen nationally in scoring. In ACC games, he is averaging a conference-best 19.9 points a game.

The model also knows that Louisville's Jarrod West is on a roll. A graduate transfer from Marshall, West has scored a season-high 14 points in each of the last two games while making 8-of-11 3-pointers (72.7 percent). West ranks third in the nation in career steals (283) among active players and ranks third in the ACC in assist-to-turnover ratio (2.42).

Now, the model has set its sights on Duke vs. Louisville. We can tell you it is leaning Over the total, predicting a combined 145 points, and it also says one side of the spread covers in almost 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Duke vs. Louisville? And which side of the spread covers in almost 60 percent of simulations? ... Join SportsLine right now to find out which side of the Louisville vs. Duke spread you should be all over Saturday, all from the model on a roll on college basketball picks!