No. 24 Kansas vs. No. 5 Duke odds, prediction: 2025 Champions Classic picks from proven model

Two Blue Blood programs clash when the 24th-ranked Kansas Jayhawks battle the fifth-ranked Duke Blue Devils at the Champions Classic on Tuesday night. Kansas is coming off a 76-57 win over Princeton on Saturday, while Duke downed Indiana State 100-62 on Friday. The Jayhawks (3-1), who have won two in a row, are 0-1 against ranked opponents this season. The Blue Devils (4-0), who are 3-0 on neutral courts, are 8-6 in the Champions Classic all-time.

Tip-off from Madison Square Garden in New York is set for 9 p.m. ET. Duke leads the all-time series 8-7, but Kansas holds a 7-6 edge in games played at neutral sites. Duke is a 10.5-point favorite in the latest Kansas vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 148.5.

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Before making any Kansas vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,000 in betting profit for $100 players on its top-rated college basketball picks over the past three-plus seasons. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

The model has simulated Kansas vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits more than 50% of the time!

So who wins Kansas vs. Duke, and which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times! 

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