The 15th-ranked Michigan Wolverines battle the 18th-ranked Oklahoma Sooners in a Big Ten-SEC Week 2 matchup on Saturday. Both teams won their season openers, with Michigan earning a 34-17 win over New Mexico, while Oklahoma defeated Illinois State 35-3. The Wolverines, who finished 8-5 overall in 2024, were 1-3 on the road last year. The Sooners, who were 6-7 last season, were 5-2 on their home field.

Kickoff is set for 7:30 p.m. ET at Gaylor Family Oklahoma Memorial Stadium in Norman, Okla. Oklahoma leads the all-time series 1-0, posting a 14-6 win in 1975. The Sooners are 4.5-point favorites in the latest Michigan vs. Oklahoma odds, while the over/under for total points scored is 43.5.

Before making any Michigan vs. Oklahoma picks, check out the college football predictions from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and  was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Michigan vs. Oklahoma 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Michigan vs. Oklahoma, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!