Most sports fans will agree: there's no better time on the sports calendar than the fall. That includes the start of football season and the first of 21 consecutive Sundays where at least two NFL games will be played, including 13 games this Sunday.

Two intriguing games round out the primetime schedule: on Sunday night, the Baltimore Ravens visit the Buffalo Bills in a rematch of their thrilling AFC Divisional Round game from last January, with Baltimore favored by 1 point and the over/under at 50.5. Meanwhile, Monday Night Football gives us the Chicago Bears hosting the Minnesota Vikings in an NFC North clash as the road team Vikings are 1.5-point favorites after originally opening as 1.5-point underdogs.

With the regular season almost underway, SportsLine expert Eric Cohen has made his exact score predictions for Week 1 of the 2025 NFL season. Before you lock in any NFL picks, make sure you see what Cohen has to say. 

A SportsLine expert and host, Cohen is evaluating the entire Week 1 NFL slate and delivers score predictions and logic for each matchup. He finished the 2024-25 season with a 190-95 record on straight up NFL picks (69%) and was profitable for bettors. 

We can tell you that Cohen likes the Bills (+1.5, 50.5) to narrowly win a rematch of their AFC Divisional Playoff Game victory over the Ravens. "In my opinion, these are the two best teams in the NFL and we'll see this matchup again on Sunday, January 25th, 2026 in the AFC Championship Game. I have Buffalo going 15-2 this season but Baltimore winning the Super Bowl. If I had to do a home field advantage ranking, the passionate Bills crowd would easily be in the top-5 if not No. 1 overall. That's the difference in a game that should be very similar to last year's playoff contest narrowly won by Buffalo." Bills 26, Ravens 23

In addition, Cohen is calling for one game to exceed 60 total points, making the Over a MUST bet! Nailing this result is key to making profitable Week 1 NFL picks. You ABSOLUTELY NEED to see which game it is before locking in any Week 11 NFL score predictions!

Who wins every Week 1 NFL game, and which game is a must bet for the over? ... Join SportsLine now to get Eric Cohen's Week 1 NFL score predictions and find out today!

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