NFL picks: 49ers among expert's best spread bets for Week 11 with focus on road teams

Week 11 features no shortage of NFL action here in the later stages of the 2025 regular season, and before you place any bets of your own, you need to check out the latest Week 10 NFL spread bets from NFL betting expert Mike Tierney, who is 25-20-1 (+240) over his last 46 NFL picks. Tierney has issued three against-the-spread best bets for Sunday's games. 

So what are Mike Tierney's best bets for Week 11 of the 2025 NFL season? Join SportsLine right now to see picks from an expert who is 25-20-1 over his last 46 NFL picks this season!