NFL DFS, Week 5: Rams vs. 49ers optimal FanDuel, DraftKings lineups for Thursday Night Football from a daily Fantasy pro

The Week 5 NFL schedule gets underway with the Los Angeles Rams hosting the San Francisco 49ers on Thursday Night Football. Kickoff is at 8:15 p.m. at SoFi Stadium. Both teams are 3-1 in 2025. The NFL DFS player pool is headlined by Christian McCaffrey, Matthew Stafford, and Puka Nacua. Should you target McCaffrey, Stafford, or Nacua, or players like Kyren Williams and Mac Jones when making NFL DFS picks or building NFL DFS stacks? Meanwhile potential NFL DFS values include Tutu Atwell, Demarcus Robinson and Marquez-Valdes Scantling.

Before setting your NFL DFS lineups on sites like DraftKings and FanDuel, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up!

Now, McClure has turned his attention to Seahawks vs. Cardinals on Thursday Night Football and locked in his top daily Fantasy football picks. 

We can tell you one of McClure's top NFL DFS picks for Thursday Night Football is Seahawks wide receiver Jaxon Smith-Njigba. Part of McClure's optimal NFL DFS strategy also includes rostering Cardinals running back Trey Benson.

McClure is also targeting a player who could go off for MASSIVE numbers for Thursday Night Football! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for Cardinals vs. Seahawks? And which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!