NFL DFS, Week 16: 49ers vs. Colts optimal lineup picks for 'Monday Night Football'

The Indianapolis Colts will host the San Francisco 49ers on 'Monday Night Football' to conclude NFL Week 16, with kickoff from Lucas Oil Stadium at 8:15 p.m. ET. The NFL DFS player pool features the likes of Christian McCaffrey, George Kittle, Jonathan Taylor and Michael Pittman Jr. Meanwhile, Ricky Pearsall (knee/ankle) is out, which could allow other San Fran wideouts to make impacts as daily Fantasy football picks. Which under-the-radar players can make the most of your NFL DFS salary cap?

Before setting your NFL DFS lineups on sites like DraftKings and FanDuel, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up!

Now, McClure has turned his attention to Colts vs. 49ers on 'Monday Night Football' and locked in his top daily Fantasy football picks. 

We can tell you one of McClure's top NFL DFS picks for 'Monday Night Football' is Niners running back Christian McCaffrey. He's also rostering Colts tight end Tyler Warren, who ranks fourth amongst tight ends in receiving yards (718) and is sixth in positional Fantasy points as a rookie.

McClure is also targeting a player who could go off for MASSIVE numbers for 'Monday Night Football!' This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for 49ers vs. Colts? And which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!

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