NFL DFS, Week 16 2025: Top FanDuel, DraftKings picks, Saturday lineups from a daily Fantasy pro

The Week 16 NFL schedule continues on Saturday with two games and a player pool that features options such as Jalen Hurts, Saquon Barkley, Caleb Williams and Jordan Love. 

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Before making any NFL DFS picks for Saturday on sites like DraftKings and FanDuel, you NEED to hear what SportsLine daily Fantasy expert Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up!

One of McClure's top NFL DFS picks for Week 16 Saturday is Barkley. He's also building around Bears tight end Colston Loveland, who should be in line for a big day with Cole Kmet (ankle/knee) listed as questionable.

McClure is also targeting an overlooked value player who could go off for MASSIVE numbers on Saturday! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who they are before locking in any lineups.

What are the top NFL DFS picks, and which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW.