NFL DFS, Week 12: Panthers vs. 49ers optimal lineup picks for 'Monday Night Football'

The San Francisco 49ers will host the Carolina Panthers on 'Monday Night Football' to conclude Week 12, with kickoff from Levi's Stadium at 8:15 p.m. ET. The NFL DFS player pool features the likes of Brock Purdy, Christian McCaffrey, George Kittle, Bryce Young and Rico Dowdle. Your daily Fantasy football strategy will also need to include under-the-radar players to conform with your NFL DFS salary cap.

Before setting your NFL DFS lineups on sites like DraftKings and FanDuel, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up!

Now, McClure has turned his attention to 49ers vs. Panthers on 'Monday Night Football' and locked in his top daily Fantasy football picks. 

We can tell you one of McClure's top NFL DFS picks for 'Monday Night Football' is 49ers tight end George Kittle. He's also rostering Panthers running back Rico Dowdle, who is averaging over 100 scrimmage yards with three total touchdowns over his last three games.

McClure is also targeting a player who could go off for MASSIVE numbers for 'Monday Night Football!' This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for Panthers vs. 49ers? And which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!

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