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NFL DFS, Week 12: Bills vs. Texans optimal FanDuel, DraftKings lineups for 'Thursday Night Football' from a daily Fantasy pro

DFS millionaire Mike McClure shares his top NFL DFS picks for Buffalo Bills vs. Houston Texans on 'Thursday Night Football'

By@Mike5754Published: Nov 21, 2025 12:33AM UTC . 3 min read

NFL Week 12 kicks off with the Houston Texans hosting the Buffalo Bills on 'Thursday Night Football'. Reigning MVP, Josh Allen, will be top-of-mind when filling out NFL DFS lineups, while others like James Cook, Nico Collins will also factor into the daily Fantasy football strategy of many managers. Elsewhere, players like Woody Marks and Xavier Hutchinson of Houston, as well as Ty Johnson and Khalil Shakir of Buffalo pose as potential sleepers. What combination of highly-price players plus underrated options should comprise your NFL DFS picks for 'Thursday Night Football'?

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Houston's C.J. Stroud (concussion) has been ruled out as have Buffalo's Dalton Kincaid (hamstring) and Curtis Samuel (neck). Receiver Keon Coleman is also inactive for the second straight week. Before setting your NFL DFS lineups on sites like DraftKings and FanDuel, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him could be way up!

Now, McClure has turned his attention to 'Thursday Night Football' and locked in his top daily Fantasy football picks. 

One of McClure's top NFL DFS picks for Thursday Night Football is Bills quarterback Josh Allen. Part of his optimal NFL DFS strategy includes rostering Texans tight end Dalton Schultz. He's come on strong as of late with Davis Mills under center, and that will be the case with C.J. Stroud still dealing with concussion symptoms. Schultz has at least six catches and 51 yards in each of the last three weeks, with one total touchdown.

McClure is also targeting a player who could go off for MASSIVE numbers for Thursday Night Football! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

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