NFL DFS Sunday Night Football picks, Week 10: 49ers vs. Chargers fantasy lineup advice for DraftKings, Fanduel from Millionaire contest winner

The Week 10 NFL schedule features a Sunday Night Football battle between two west coast teams looking to keep pace in their respective playoff races with Jimmy Garoppolo and the San Francisco 49ers set to host Justin Herbert and the Los Angeles Chargers at Levi's Stadium.. Caesars Sportsbook expects this game to be one-sided with the 49ers listed as 7.5-point favorites in the latest 49ers vs. Chargers odds. With an over/under of 45.5 points, this game could feature multiple high-scoring players in the DFS player pool. Before locking in any NFL DFS lineups for Sunday Night Football on sites like DraftKings and FanDuel, you NEED to see what Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who has been cashing big all season, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

Kaylor has been spot-on all season, hitting on epic NFL DFS picks in primetime showdown matchups like Jerry Jeudy (4-102-1), Stefon Diggs (12-148-3), Amari Cooper (7-101-1), Nick Chubb (23-113-1), CeeDee Lamb (8-87-1), Deebo Samuel (6-115-1) Cooper Kupp (14-122), Travis Kelce (7-25-4), Davante Adams (3-124-2), Justin Fields (179-1-1, 82-1), Diggs again in Week 8 (6-106-1), Chubb (23-101-2) and Cooper (5-131-1) again on MNF in Week 8, and Kelce again on Week 9 SNF (10-106). . Anyone who has followed his picks is WAY UP!

Now, Kaylor has turned his attention to Chargers vs. 49ers on Week 10 Sunday Night Football and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for the Chargers-49ers SNF matchup is San Francisco running back Christian McCaffrey. "Christian McCaffrey has fit seamlessly into Kyle Shanahan's offense and this is a great spot for him on Sunday Night Football. The Chargers are allowing 145.5 rushing yards per game, and similar running backs have had huge days against them. In Week 7, Seahawks RB Kenneth Walker III erupted for 167 yards and two touchdowns, and in Week 9, the Falcons combined to rush for 201 yards and two TDs against Los Angeles. McCaffrey should be fully integrated into the 49ers offense, and I expect he will have his most productive game in a San Francisco uniform on Sunday night. Look for the former All-Pro to finish with close to 150 combined yards and a touchdown."

Kaylor is also targeting another under the radar option for SNF who could post HUGE numbers and carry your lineups to victory on Sunday night. This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for Titans vs. Chiefs on FanDuel and DraftKings? And which player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!