NBA DFS, 2025: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, Nov. 19 from a daily Fantasy pro

The NBA features a nine-game schedule on Wednesday, providing a rather robust NBA DFS player pool. Stars like Kevin Durant, LaMelo Ball and Nikola Jokic will take the floor, while others like Zion Williamson (hamstring), Bam Adebayo (toe) and Jalen Brunson (ankle) are listed as questionable. What combination of highly-priced superstars and economical role players should comprise your daily Fantasy basketball strategy?

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Before making any NBA DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best NBA DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any NBA DFS player.

For Wednesday, one of McClure's top NBA DFS picks is Timberwolves shooting guard Anthony Edwards at $9,100 on DraftKings and $9,300 on FanDuel. He's also rostering Pacers center Isaiah Jackson ($4,200 on DraftKings and $4,600 on FanDuel), who is coming off a double-double with 16 points, 10 rebounds, 3 assists, 2 steals and 1 block. Jackson has reached double-figures in scoring three times in his last five games after doing so the same number of times over his first nine games.

McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top NBA DFS picks for Wednesday? And which player is a must-roster? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NBA DFS!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month at SportsLine for $1! JOIN NOW.