MLB odds, lines, picks: Advanced computer model includes the Astros in parlay for Sept. 20 that would pay almost 25-1

Yankees slugger Aaron Judge continues his record-setting home run push when the New York Yankees host the Pittsburgh Pirates on Tuesday in the first game of a short two-game series at Yankee Stadium in the Bronx. The leading candidate for the AL MVP award, Judge has 59 home runs, two shy of Roger Maris' single-season AL record set in 1961. 

New York is a -335 favorite in the latest Yankees vs. Pirates odds from Caesars Sportsbook, while Pittsburgh is a +260 underdog. The over/under for runs scored is 8. First pitch is set for 7:05 p.m. ET. The game is one of 16 on the MLB schedule for Tuesday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 321-272 on top-rated MLB money-line picks since the start of the 2021 season, returning more than $600 for $100 bettors during that span. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.

Now, the model has set its sights on the MLB schedule for Tuesday, Sept. 20, and has generated a four-leg parlay that would pay almost 25-1! The parlay doesn't start until 6:40 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Astros (+122) to beat the Rays. But the model has three other picks, including a play on an even bigger AL underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of almost 25-1? ... Join SportsLine right now to find out which picks you should be all over on Tuesday, all from the model that is on a 321-272 run on top-rated MLB money-line picks since the start of 2021!