MLB DFS: Optimal FanDuel, DraftKings picks, player pool, fantasy lineup advice for Wednesday, May 21, 2025
Daily Fantasy millionaire Mike McClure shares his top MLB DFS picks and stacks for Wednesday
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The Wednesday MLB schedule features a pretty even mix of afternoon and night games for daily Fantasy baseball players to form MLB DFS lineups from over multiple slates. The night slate features multiple intriguing matchups, including the Dodgers facing the Diamondbacks after Los Angeles snapped a season-high four-game losing streak after scoring three runs in the bottom of the 10th inning of a comeback victory on Tuesday. Depending on the weather in New York, Jacob deGrom, who won two Cy Young awards with the Mets, could make his New York City return when the Rangers play the Yankees in the Bronx. How should deGrom factor into your MLB DFS strategy, along with Yankees in the MLB DFS player pool such as Aaron Judge, Paul Goldschmidt and Anthony Volpe?
Before setting your MLB DFS lineups on daily Fantasy sites like DraftKings and FanDuel for Wednesday, May 21, you NEED to see the top MLB DFS picks from Mike McClure. McClure is a daily Fantasy pro with over $2 million in career winnings.
When it comes to MLB, McClure is at his best. Recognized in the book "Fantasy Football (and Baseball) for Smart People: How to Turn Your Hobby into a Fortune," McClure's proprietary MLB DFS projection model simulates each game 10,000 times, taking factors such as matchups and recent results into account. This allows him to find the best values on every site.
On Tuesday, McClure identified Astros third baseman Isaac Paredes as one of his value plays and one of his top MLB DFS picks on both sites. The result: Paredes went 1-for-4 with a home run and a walk, returning 16 points on DraftKings and 21.7 points on FanDuel. Anybody who included him in their lineups could have been well on the way to a profitable day!
One of McClure's top MLB DFS picks for Wednesday is Phillies third baseman/first baseman Alec Bohm, who is $4,300 on DraftKings and $3,200 on FanDuel for MLB DFS lineups. McClure is also rostering Angels shortstop Zach Neto ($4,600 on DraftKings and $3,500 on FanDuel). The 24-year-old enters on a five-game hitting streak with five RBI over that span. Neto is going up against Athletics left-handed pitcher JP Sears and he is 4-for-7 with a home run over his career against Sears.
McClure is also targeting a player who is set to EXPLODE for huge numbers on Wednesday! The stars are aligning for him to return tournament-winning value, and he comes at a price that won't break the bank. This pick could be the difference between cashing in big or going home with nothing!
What players can you bank on in MLB DFS for Wednesday, and which undervalued player is a MUST-ROSTER?... Join SportsLine now to see DFS pro Mike McClure's top picks and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!
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