MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, May 13 from a daily Fantasy pro

There's a full 15-game slate on Wednesday's MLB schedule, with 13 contests starting at 6:40 p.m. ET or later. Cardinals vs. Athletics has the highest O/U of the slate at 10, so daily Fantasy baseball managers may target that matchup when searching for MLB DFS picks. The likes of Ivan Herrera, Jordan Walker and Nick Kurtz are some of the best sluggers from this game in the MLB DFS player pool, but there also may be undervalued options, specifically for the A's since they just placed All-Star shortstop, Jacob Wilson, on the IL.

Before making any MLB DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best MLB DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any MLB DFS player.

For Wednesday, one of McClure's top MLB DFS picks is Cubs third baseman Alex Bregman ($3,700 on DraftKings, $2,800 on FanDuel). He's also building around Mariners outfielder Julio Rodriguez ($4,500 on DraftKings, $3,100 on FanDuel), who is heating up after a slow start. The three-time All-Star has three home runs and a 1.066 OPS over his last six games, averaging three total bases per game over this stretch.

McClure is also targeting a surprising player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top MLB DFS picks for Wednesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!