MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, April 22 from a daily Fantasy pro

All 30 MLB teams are in action on Wednesday's MLB schedule, but half-a-dozen of them take place in the afternoon. Even with that, the MLB DFS player pool is still stacked with the likes of Bryce Harper, Fernando Tatis Jr., Oneil Cruz and Corbin Carroll in action. On the mound -- and at the plate -- will be Shohei Ohtani, while other top pitchers available for MLB DFS picks include Braxton Ashcraft, Matthew Boyd and Eduardo Rodriguez.

Before making any MLB DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best MLB DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any MLB DFS player.

For Wednesday, McClure is rostering Padres outfielder Jackson Merrill at $5,300 on DraftKings and $3,800 on FanDuel. McClure is also constructing his MLB DFS strategy around Diamondbacks catcher James McCann ($2,400 on both DraftKings and FanDuel). After a slow start to the year, McCann is now on a five-game hitting streak with a .389 average and 7 RBI over this stretch.

McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top MLB DFS picks for Wednesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!