MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, April 1 from a daily Fantasy pro

The first full Wednesday of the 2026 MLB season has arrived, with all 30 teams in action. You'll have to lock in your MLB DFS lineups early with most of the contests being afternoon games with it being getaway day. The top options on the mound for Wednesday's daily Fantasy baseball picks are Paul Skenes, Jacob Misiorowski, Tarik Skubal and Garrett Crochet.

Before making any MLB DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best MLB DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any MLB DFS player.

For Wednesday, one of McClure's top MLB DFS picks is Phillies DH Kyle Schwarber at $6,200 on DraftKings and $4,200 on FanDuel. He's also stacking Schwarber with shortstop Trea Turner ($5,200 on DraftKings, $3,600 on FanDuel), who won his second career batting title last season and is 3 for 7 (.429) off Wednesday's starter Cade Cavalli.

McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top MLB DFS picks for Wednesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!