MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Tuesday, April 21 from a daily Fantasy pro

All 30 MLB teams are in action on Tuesday, with the first pitch coming at 6:10 p.m. ET. Plenty of MLB DFS players will target the likes of Yordan Alvarez, Jordan Walker and Ben Rice, considering their hot starts to the season. One also shouldn't overlook Arizona's Ildemaro Vargas as an underrated part of a Tuesday MLB DFS strategy as he's riding a 15-game hit streak that's the longest active in baseball. Meanwhile, options on the mound tonight include Luis Castillo, Yoshinobu Yamamoto and Shota Imanaga.

Before making any MLB DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best MLB DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any MLB DFS player.

For Tuesday, McClure is rostering Dodgers outfielder Kyle Tucker at $6,600 on DraftKings and $3,800 on FanDuel. McClure is also constructing his MLB DFS strategy around Mets outfielder MJ Melendez ($2,100 on DraftKings, $2,600 on FanDuel). Melendez just made his season debut last week, but he's gone 5 for 14 (.357) with three extra base hits since then.

McClure is also targeting a player who could go off for massive numbers on Tuesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top MLB DFS picks for Tuesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!