Michigan State vs. No. 25 Iowa odds, line: Advanced model reveals college basketball picks, predictions for Feb. 22, 2022

Big Ten rivals match up when Michigan State (18-8) and No. 25 Iowa (18-8) battle it out on Tuesday evening at 7 p.m. ET. Michigan State has lost two games in a row. In their last contest, the Spartans lost to No. 15 Illinois 79-74. Iowa won four of its last five games. On Feb. 19, Iowa topped No. 22 Ohio State 75-62. Iowa is favored by six points and the over-under for total points is set at 153.5 at Caesars Sportsbook.

Before making any Michigan State vs. Iowa picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.  

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Iowa sophomore forward Keegan Murray is the clear No. 1 option for this squad. He is first in the Big Ten in scoring (23.4), fourth in blocks (2.1) and he also averages 8.2 rebounds. Murray has logged 20-plus points in six straight games. In the victory over Ohio State, he finished with 24 points, five rebounds and went 10-for-17 from the field. 

The model also knows Michigan State junior forward Malik Hall averages 9.8 points and 4.9 rebounds. He has been a marksman for the Spartans, shooting 51 percent from downtown. Hall has scored in double figures in six of the last 10 games he's played in. On Feb. 1 against Maryland, Hall had 16 points and four rebounds.

Now, it has set its sights on Michigan State vs. Iowa. We can tell you the model is leaning under the total and it also says one side of the spread hits in over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Michigan State vs. Iowa? And which side of the spread hits in over 60 percent of simulations? ... Join SportsLine right now to find out which side of Michigan State vs. Iowa spread you should be all over Tuesday, all from the model on a roll on college basketball picks!