Miami (Ohio) vs. Buffalo MACtion odds, line: 2025 college football picks for Week 13 predictions from proven model

Teams looking to stay in the Mid-American Conference championship game conversation clash when the Miami (Ohio) RedHawks take on the Buffalo Bulls in MACtion on Wednesday night. The RedHawks (5-5, 4-2 MAC), who have lost two in a row, are 2-3 on the road this season. The Bulls (5-5, 4-2 MAC), who are tied with four other teams including Miami for second in the conference, are 2-3 on their home field.

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Kickoff from UB Stadium in Buffalo, N.Y., is at 7 p.m. ET. Miami leads the all-time series 17-9. The RedHawks are 2.5-point favorites in the latest Miami vs. Buffalo odds, while the over/under for total points scored is 38.5.

Before making any Miami vs. Buffalo picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

The model has simulated Miami vs. Buffalo 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Miami vs. Buffalo, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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