Mario Barrios vs. Ryan Garcia odds, picks: Accomplished boxing analyst reveals top selections for Feb. 21 showcase

Mario Barrios defends the WBC welterweight title Saturday in a 12-round boxing main event against Ryan Garcia. The pay-per-view main card (DAZN) is set for an 8 p.m. ET star from T-Mobile Arena in Las Vegas.

Garcia is a -270 favorite (wager $270 to win $100), while Barrios is priced at +210 (wager $100 to win $210) in the latest boxing odds for Mario Barrios vs. Ryan Garcia. The over/under for total rounds finished is 10.5 (Over -130).

Before locking in your Mario Barrios vs. Ryan Garcia picks, you NEED to see the boxing predictions and betting advice from SportsLine analyst Josh Nagel.

Nagel, who is the combat sports editor for SportsLine, is an experienced and successful boxing analyst. He previously served as SportsLine's main boxing analyst and covered the sport for multiple outlets for more than 20 years. He has recently returned to his role as SportsLine's top boxing analyst and had a massively profitable 2025 campaign. Perhaps his biggest winner was calling Terence Crawford (+140) against Canelo Alvarez in their September mega fight, while also correctly advising SportsLine members to take Crawford specifically by decision (+220). His other notable 2025 winners include calling Dimitry Bivol (+110) to pull the slight upset of Artur Beterbiev in their February rematch. In April, he correctly called Jarron Ennis to beat Eimantas Stanionis by KO (+155) while also correctly predicting the Under 10.5 rounds (+165). He also correctly predicted Jake Paul by decision (-110) against Julio Cesar Chavez Jr. in June. He kept his hot streak going by recommending Katie Taylor (+170) against Amanda Serrano in their trilogy showdown in July. Anyone who has followed Nagel's combat sports picks this year could already be up more than $2,500!

Now, with Mario Barrios vs. Ryan Garcia approaching, Nagel has studied the boxing match from every angle and released confident picks on the money line, total rounds completed and a method-of-victory prop. 

We can tell you he likes the fight to go Over 10.5 rounds, and he's also locked in a method-of-victory prop that returns better than +300! You ABSOLUTELY need to see Nagel's picks before making any of your own!

Who wins Mario Barrios vs. Ryan Garcia, and which method of victory prop presents massive value? ... Join SportsLine here to see which bets you need to make for the fight, all from the accomplished veteran combat sports analyst who has consistently delivered winners!