LSU vs. Vanderbilt odds, line, spread: Proven model reveals college basketball picks, predictions for Feb. 22, 2023

An SEC battle is on tap between the LSU Tigers and the Vanderbilt Commodores at 7 p.m. ET Wednesday at Pete Maravich Assembly Center. LSU is 12-15 overall and 9-7 at home, while Vanderbilt is 15-12 overall and 4-5 on the road. The Commodores are ranked fifth in the SEC; LSU is ranked 14th. 

The Commodores are favored by 2.5 points in the latest LSU vs. Vanderbilt odds from Caesars Sportsbook, and the over/under is set at 140. Before you make any Vanderbilt vs. LSU picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 16 of the season 71-42 on all-top rated college basketball picks this season, returning more than $1,700 for $100 players. Anybody who has followed it has seen huge returns.

Now, it has simulated LSU vs. Vanderbilt 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins LSU vs. Vanderbilt? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!