Knicks vs. Pistons odds, line: Proven model reveals picks for NBA matchup on Friday, Feb. 6

Eastern Conference powers meet on Friday when the New York Knicks travel to take on the Detroit Pistons. These teams sit No. 1 and No. 2 in the East with Detroit atop the standings with a 37-12 overall mark, while New York is five games back at 33-18. 

Tipoff is 7:30 p.m. ET at Little Caesars Arena. The latest Knicks vs. Pistons odds list Detroit as a 2-point favorite, while the over/under is 222.5. 

Before making any Pistons vs. Nuggets picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 16 of the 2025-26 NBA season on a sizzling 38-16 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated this matchup 10,000 times and the results are in. We can tell you that the model is going Over on the point total, and it also says one side of the spread hits in nearly 70% of simulations!

Who wins Nuggets vs. Pistons, and which side of the spread hits nearly 70% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 38-16 roll on top-rated NBA picks!