Knicks vs. Cavaliers odds, line, spread, time: 2025 NBA picks, October 22 predictions from proven model

Two Eastern Conference contenders will face off in their first games of the 2025-26 NBA season as the Cleveland Cavaliers visit the New York Knicks on Wednesday. Cleveland went an East-best 64-18 last season before being knocked out in the second round of the playoffs, while the Knicks are coming off a 51-31 season and Eastern Conference Finals appearance. The Cavaliers swept the season series with New York last year, winning all four games.

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Tipoff is set for 7 p.m. ET from Madison Square Garden in New York City. The latest Cavaliers vs. Knicks odds, according to the SportsLine consensus, have Cleveland as the 1.5-point favorite. The over/under is 228.5 points.

Before entering any Knicks vs. Cavaliers picks, you'll want to see the NBA predictions from the model at SportsLine.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past seven seasons. The model enters the 2025-26 NBA season on a sizzling 160-118 roll on all top-rated NBA picks, returning nearly $4,000. It also went 24-11 (69%) on top-rated NBA against-the-spread picks last season. Anyone following could have seen HUGE returns!

The model has simulated Knicks vs. Cavaliers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits over 50% of the time!

So who wins Cavs vs. Knicks, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the Knicks vs. Cavs spread you need to jump on, all from the computer model that has crushed its NBA picks!

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