Iowa vs. Iowa State odds, lines: Advanced model reveals college football picks and predictions

The Iowa Hawkeyes take on their in-state rival the Iowa State Cyclones in the battle for the Cy-Hawk Trophy. The Hawkeyes cruised to a Week 1 win against the Indiana Hoosiers. The Cyclones narrowly defeated the Northern Iowa Panthers. Iowa State is favored by 4.5 points in the latest odds from Caesars Sportsbook, while the Over-Under is set at 45.5 points. Kickoff from Ames, Iowa is set for 4:30 p.m. ET. 

Before you make any Iowa vs. Iowa State picks, you'll want to see the college football predictions from the SportsLine Projection Model.