Indiana vs. Wyoming odds, line: Advanced model reveals 2022 NCAA Tournament First Four picks, best bets for Mar. 15

The 2022 NCAA Tournament kicks off with a matchup between the No. 12 seed Indiana Hoosiers (20-13) and the No. 12 seed Wyoming Cowboys (25-8) at 9:10 p.m. ET on Tuesday night. Indiana is favored by four points at Caesars Sportsbook, while the Over-Under is set at 132.5 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Indiana vs. Wyoming picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Indiana junior forward Trayce Jackson-Davis is averaging 18.1 points, 8.2 rebounds and 2.4 blocks per game. The Indiana native has been a reliable offensive threat for the Hoosiers. He's scored more than 20 points in three straight games. In his last outing, Jackson-Davis recorded a double-double, finishing with 31 points, 10 rebounds and shot 15-for-21 from the floor. 

The model also knows Wyoming sophomore forward Graham Ike has been a force down low. He is leading the team in scoring (19.6), rebounding (9.6) while shooting 51 percent from the field. The Colorado native has tallied five double-doubles over his last 10 games. On Feb. 26 against Nevada, Ike had 23 points and 15 rebounds. 

Now, it has set its sights on Indiana vs. Wyoming. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in almost 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Indiana vs. Wyoming? And which side of the spread hits in almost 60 percent of simulations? ... Join SportsLine right now to find out which side of Indiana vs. Wyoming spread you should be all over Tuesday, all from the model on a roll on college basketball picks!

Here are the computer's selections for Indiana vs. Wyoming. Simulations run every 15 minutes and are subject to change. SportsLine members can always get the latest picks on the game forecast page.

Indiana vs. Wyoming | 3/15 | 9:10 p.m. ET

Against The Spread

Pick: Wyoming +4
The Cowboys cover in 57 percent of simulations

Over-Under
Pick: Over 132.5
The Over hits in 66 percent of simulations 

Projected Final Score: Indiana 70, Wyoming 69

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