Dodgers vs. Guardians odds, line, start time, picks, best bets for May 28 matchup from proven model

The Los Angeles Dodgers will look for the series sweep when they battle the Cleveland Guardians in the final game of their three-game interleague series on Wednesday. The Dodgers (34-21), who have won two in a row, are 15-13 on the road this season. The Guardians (29-25), who have dropped three straight, are 14-10 on their home field in 2025.

First pitch from Progressive Field in Cleveland is set for 1:10 p.m. ET. Los Angeles is a -156 favorite on the money line (risk $156 to win $100) in the latest Dodgers vs. Guardians odds, while the total number of runs Vegas thinks will be scored, or the over/under, is 9 in the latest MLB odds. 

Before you make any Dodgers vs. Guardians picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 10 of the 2025 MLB season on a profitable 27-21 run (56%) on top-rated MLB picks. Anybody following could have seen strong returns!

The model has simulated Dodgers vs. Guardians 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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