The Chicago Cubs and Cincinnati Reds open a three-game series on Friday afternoon at Wrigley Field in Chicago. First pitch is at 2:20 p.m. ET. William Hill Sportsbook lists Chicago as the -177 favorite (risk $177 to win $100) in the latest Cubs vs. Reds odds. The Over-Under for total runs scored is 6.5. (See the latest lines for every game on our MLB odds page in this matchup.)

Before making any Reds vs. Cubs picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a fast start in 2021, going 61-44 on top-rated MLB money-line picks through eight weeks, returning well over $700. Anyone following it has seen huge rewards!

Now, it has set its sights on Cubs vs. Reds. We can tell you it's leaning Over the total, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Cubs vs. Reds? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the Reds vs. Cubs money line you should be all over on Friday, all from the model that was up more than $1,400 on MLB picks in 2019!