The No. 23 Creighton Bluejays and Seton Hall Pirates meet for the second time this season on Wednesday evening in a showdown between two of the top five teams in the Big East. Creighton was clinical in its 83-61 win against Seton Hall on January 3, and after going 6-2 since then, has played itself back into the AP Top 25. While the Pirates haven't been ranked at any point this season, they have gone 7-1 since that loss to the Bluejays.

Tip-off from the Prudential Center, where Seton Hall is 8-3 this season, is set for 6:30 p.m. ET. The Bluejays are favored by 4 points in the latest Creighton vs. Seton Hall odds from Caesars Sportsbook, while the over/under is set at 135.5. Before you make any Seton Hall vs. Creighton picks and predictions, you HAVE to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 14 of the season 57-37 on all top-rated college basketball picks this season, returning more than $1,000 for $100 players. Anybody who has followed it has seen HUGE returns. 

Now, it has simulated Creighton vs. Seton Hall 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread holds all of the value! You ABSOLUTELY need to see it before locking in your own picks.

Who wins Creighton vs. Seton Hall? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks, and find out!