Colts vs. Seahawks odds, line, spread: Proven model reveals NFL picks, predictions for Week 1, 2021

The Indianapolis Colts will take on the Seattle Seahawks at 1 p.m. ET on Sunday at Lucas Oil Stadium. The Seahawks went 12-4 last season and won the NFC West, but lost in the first round of the playoffs to the Rams. The Colts finished with an 11-5 record and lost in the first round of the AFC playoffs to the Bills. 

Seattle is favored by three points in the latest Colts vs. Seahawks odds from Caesars Sportsbook, and the over-under is set at 49. Before you make any Seahawks vs. Colts picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, it has simulated Colts vs. Seahawks 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Colts vs. Seahawks? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!