Colts vs. Bills line, predictions: Advanced computer model releases NFL picks for Saturday's matchup

The NFL's Super Wild Card Weekend kicks off Saturday with an AFC showdown between the Indianapolis Colts (11-5) and Buffalo Bills (13-3). Kickoff is set for 1:05 p.m. ET. Buffalo is a 6.5-point favorite in the latest Colts vs. Bills odds at William Hill Sportsbook, while the Over-Under is 51.5 (For the latest NFL predictions for every wild-card playoff game this week, check out our NFL odds page). 

Before making any Colts vs. Bills picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 23-13 on top-rated NFL picks this season, returning well over $800. The model also enters the 2021 NFL Playoffs on an incredible 119-77 run on top-rated NFL picks that dates back to the 2017 season.

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is WAY UP.

Now, it has set its sights on Colts vs. Bills. We can tell you the model is leaning Under the total, and it also says one side of the spread cashes in more than 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Colts vs. Bills on Saturday? And which side of the spread hits over half the time? ... Join SportsLine right now to find out which side of the Colts vs. Bills spread you should be all over, all from the model on a 119-77 roll on NFL picks!