Before making any Week 7 college football predictions, be sure to check out the college football picks and parlay from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. After opening this season 11-9, including a 3-0 sweep in Week 4, he's now on an 24-15 roll in his SportsLine best bets column dating back to last season!

Now, he's turned his attention to the 2025 Week 7 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

For this week, Casale is going Over 53.5 in the big Oregon vs. Indiana matchup on Saturday.

"Curt Cignetti is one of the best coaches in the country, although I thought he played a little conservative early on in losses to Ohio State and Notre Dame last season," Casale said. "This is just a hunch, but I think we see Cignetti be much more aggressive here in the underdog role to try and put pressure on Oregon."

Casale has also found two other college football picks he loves, including backing a shocking underdog that could win outright against a team "in an awful spot." You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 7 in the 2025 college football season, and which underdog could win outright? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation who is on a 24-15 roll on his best bets!

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