Before making any Week 5 college football predictions, be sure to check out the college football picks from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. After opening this season 9-5, including a 3-0 sweep in Week 4, he's now on an 22-11 roll in his SportsLine best bets column dating back to last season!

Now, he's turned his attention to the 2025 Week 5 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

For Week 5, Casale is backing No. 3 Penn State (-3.5) against No. 6 Oregon in a 7:30 p.m. ET matchup on Saturday.

"This is a good spot to back Penn State," Casale said. "As good as Oregon has looked, the Ducks still haven't beaten a team with a heartbeat. Penn State hasn't either, but there is one big difference, the Nittany Lions are the more experienced team with a lot of players that have been in the program for a couple of years."

Casale has also found two other college football picks he loves, including fading a national power in a "sneaky tough game." You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 5 in the 2025 college football season, and which lines should you jump on now? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation who is on a 22-11 roll on his best bets!