The Week 2 college football schedule begins Friday with four games and is followed by some intriguing matchups on Saturday as teams look for early College Football Playoff positioning. Among the notable Week 2 college football odds, Oklahoma is -5.5 against Michigan, Oregon is -27.5 against Oklahoma State, Illinois is -3 versus Duke, and Arizona State is -6.5 versus Mississippi State. Conference matchups include Ole Miss vs. Kentucky (+9.5) and Virginia vs. NC State (-3).

Before making any Week 2 college football predictions, be sure to check out the Week 2 college football picks from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. After opening this season 3-2, he's now on a 16-8 roll in his SportsLine best bets column dating back to last season!

Now, he's turned his attention to the 2025 Week 2 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

For Week 2, Casale is backing Kansas State (-17) against Army. "This version of the Army option attack isn't nearly as potent and we saw that in Week 1 when Tarleton State held the Black Knights to 5.0 yards per play. I expect Kansas State's defense to dominate this game and cover the big spread at home."

Casale has also found another college football picks he loves, saying a big underdog "is live to win its game outright"! You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 2 in the 2025 college football season, and which lines should you jump on now? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation who is on a 16-8 roll on his best bets!